Translational Pharmacology

Translational Pharmacology

The challenge for Translational Pharmacology is to improve the predictive value of the tools that are used to qualify the efficacy of a drug candidate. We should briefly consider the range of these tools and provide conjecture as to where the limitations may be and how these may be addressed. As this section of Frontiers develops, we will specifically welcome manuscripts that address ways of im...

Translational Systems Pharmacology Studies in Pregnant Women

Pregnancy involves rapid physiological adaptation and complex interplay between mother and fetus. New analytic technologies provide large amounts of genomic, proteomic, and metabolomics data. The integration of these data through bioinformatics, statistical, and systems pharmacology techniques can improve our understanding of the mechanisms of normal maternal physiologic changes and fetal devel...

Global HIV/AIDS Clinical and Translational Pharmacology

1Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14260, USA 2Translational Pharmacology Research Core, New York State Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicot Street, Buffalo, NY 14302, USA 3Department of Pharmacology and Physiology, Center for Human Experimental Therapeutics, Clinical and Translati...

Clinical pharmacology as a foundation for translational science.

Translational systems pharmacology‐based predictive assessment of drug‐induced cardiomyopathy

Drug-induced cardiomyopathy contributes to drug attrition. We compared two pipelines of predictive modeling: (1) applying elastic net (EN) to differentially expressed genes (DEGs) of drugs; (2) applying integer linear programming (ILP) to construct each drug's signaling pathway starting from its targets to downstream proteins, to transcription factors, and to its DEGs in human cardiomyocytes, a...